Thomas Tuchel makes three changes from our midweek Champions League tie.
Andreas Christensen, Jorginho and captain Cesar Azpilicueta are the returning trio in place of Thiago Silva, N’Golo Kante and Ruben Loftus-Cheek.
The Blues are expected to line up in our usual 3-4-3 system with the front three of Kai Havertz, Mason Mount and Timo Werner unchanged after two of them scored in Madrid on Tuesday night.
Christensen joins Antonio Rudiger and Reece James at the back, while Azpilicueta and Marcos Alonso are expected to be deployed at wing-back. Mateo Kovacic keeps his place in midfield alongside Jorginho.
Crystal Palace are altered by four from their most recent outing, with goalkeeper Jack Butland returning along with Joel Ward, captain James McArthur and Ebere Eze. On-loan Conor Gallagher is ineligible to face his parent club.
Chelsea (3-4-3) Mendy; James, Christensen, Rudiger; Azpilicueta (c), Jorginho, Kovacic, Alonso; Mount, Havertz, Werner
Subs Kepa, Thiago Silva, Sarr, Kante, Loftus-Cheek, Saul, Pulisic, Ziyech, Lukaku
Crystal Palace (4-3-3) Butland; Ward, Andersen, Guehi, Mitchell; Kouyate, McArthur (c), Schlupp; Eze, Mateta, Zaha
Subs Guaita, Clyne, Kelly, Tomkins, Milivojevic, Ayew, Olise, Benteke, Edouard
The referee is Anthony Taylor