There is a Chelsea debut for Pierre-Emerick Aubameyang and a return in goal for Kepa Arrizabalaga.
Thomas Tuchel makes six changes from our weekend win over West Ham, with Mason Mount, Kai Havertz, Ben Chilwell and Cesar Azpilicueta also back in the starting 11.
Kepa is between the posts behind an expected back three of Wesley Fofana, Kalidou Koulibaly and Azpilicueta, with Reece James and Ben Chilwell at wing-back, the latter making his 50th Chelsea start following a match-changing cameo against the Hammers.
Aubameyang leads the attack alongside Raheem Sterling and Havertz, while Mount and Mateo Kovacic are in midfield, the latter making his return to former club Dinamo Zagreb.
Croatian internationals Bruno Petkovic and Dino Peric start for the hosts.
Chelsea (3-4-3) Kepa; Azpilicueta (c), Fofana, Koulibaly; James, Mount, Kovacic, Chilwell; Havertz, Aubameyang, Sterling
Subs Bettinelli, Mendy, Cucurella, Chalobah, Chukwuemeka, Gallagher, Jorginho, Loftus-Cheek, Zakaria, Pulisic, Ziyech, Broja
Dinamo Zagreb (3-5-2) Livakovic; Moharrami, Sutalo, Peric; S.Ristovski, Ademi (c), J.Misic, Ivanusec, Ljubicic; Petkovic, Orsic
Subs Zagorac, Nevistic, Stefulj, Lauritsen, Baturina, Emreli, Bockaj, Drmic, Marin, Theophile-Catherine, Bulat, Spikic
The referee is Istvan Kovacs from Romania