Frank Lampard makes four changes to the Chelsea team that started in Madrid last week, two of which are enforced.
Chelsea vs Real Madrid lineups
Kalidou Koulibaly is out injured and Ben Chilwell suspended, so neither is involved. Attackers Joao Felix and Raheem Sterling are the other players to make way.
In come Marc Cucurella, Trevoh Chalobah, Conor Gallagher and Kai Havertz. Chalobah and Cucurella for Koulibaly and Chilwell look like straight swaps, with Reece James continuing at right wing-back and Thiago Silva and Wes Fofana in the back three.
Gallagher and Havertz meanwhile are expected to play in front of Enzo, N’Golo Kante and Mateo Kovacic.
The bench includes Sterling and Joao Felix, as well as youngsters Carney Chukwuemeka and Lewis Hall.
Real Madrid are unchanged from the first leg.
Chelsea: Kepa, Chalobah, Thiago Silva (c), Wes Fofana, James, Kante, Enzo, Kovacic, Cucurella, Gallagher, Havertz.
Substitutes: Mendy, Azpilicueta, Hall, Chukwuemeka, Loftus-Cheek, Zakaria, Mount, Mudryk, Pulisic, Sterling, Ziyech, Joao Felix
Real Madrid: Courtois, Carvajal, Militao, Alaba, Camavinga, Modric, Valverde, Kroos, Rodrygo, Benzema (c), Vinicius
Substitutes: Lunin, Lopez, Vallejo, Nacho, Odriozola, Rudiger, Ceballos, Tchouameni, Vazquez, Hazard, Asensio, Diaz
Referee Daniele Orsato from Italy