Enzo Maresca has selected a similar side to the one that started against Barrow last Tuesday, with 11 changes in total from the weekend win over Brighton.
Filip Jorgensen is named in goal with the defence ahead of him comprising of captain Axel Disasi, Toisin Adarabioyo, Benoit Badiashile and Renato Veiga.
Cesare Casadei and Kiernan Dewsbury-Hall are the central midfielders. Ahead of them Pedro Neto, Joao Felix, Mykhailo Mudryk and Christopher Nkunku make up an exciting front four.
Wesley Fofana, Romeo Lavia and Cole Palmer were not named in our Conference League squad as their minutes are managed this season.
Academy midfielder Kiano Dyer, 17, is named on the bench for the first time.
Eidur Gudjohnsen's son, Andri, starts for Gent.
Chelsea: Jorgensen; Disasi (c), Tosin, Badiashile, Veiga; Casadei, Dewsbury-Hall; Neto, Joao Felix, Mudryk; Nkunku
Subs: Sanchez, Bergstrom, Colwill, Cucurella, Caicedo, Enzo Fernandez, Dyer, George, Madueke, Guiu
Gent: Roef; Gambor, Watanabe, Mitrovic (c), Brown, Torunarigha, Ito, Delorge, Fadiga, Gudjohnsen, Surdez
Subs: Schmidt, Gandelman, Vancsa, Gerkens, Sonko, Samoise, Araujo, Dean, Kums, Fortuna, De Vlieger, Varela
The referee is Daniel Schlager from Germany.