In defence, Thiago Silva and Levi Colwill return. Benoit Badiashile and Marc Cucurella make way, meaning Colwill is expected to reprise the left-back role he has been used in frequently this season.

Pochettino’s other alteration to the side that started the Blackburn victory comes in midfield, where Moises Caicedo is selected ahead of Lesley Ugochukwu. The front three of Cole Palmer, Nicolas Jackson and Raheem Sterling remains unchanged.

Reece James starts his first Premier League game since the opening day, while Mykhailo Mudryk returns to the bench after injury.

Tottenham make two changes to their most recent starting XI. Destiny Udogie and Brennan Johnson replace Ben Davies and Richarlison.

Chelsea: Sanchez; James (c), Disasi, Thiago Silva, Colwill, Caicedo, Enzo, Palmer, Gallagher, Sterling, Jackson

Subs: Petrovic, Gusto, Cucurella, Maatsen, Badiashile, Ugochukwu, Madueke, Mudryk, Washington

Tottenham: Vicario, Porro, Romero, van de Ven, Udogie, Bissouma, Sarr, Kulusevski, Maddison, Johnson, Son

Subs: Forster, Skipp, Hojbjerg, Gil, Emerson, Dier, Lo Celso, Richarlison, Bentancur